Lappaol F, a Novel Anticancer Agent Isolated from Plant Arctium Lappa L.
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چکیده
منابع مشابه
Small Molecule Therapeutics Lappaol F, a Novel Anticancer Agent Isolated from Plant Arctium Lappa L
In an effort to search for new cancer-fighting therapeutics, we identified a novel anticancer constituent, Lappaol F, fromplantArctiumLappaL. Lappaol F suppressed cancer cell growth in a timeanddose-dependent manner inhumancancer cell lines of various tissue types.We found thatLappaol F inducedG1 andG2 cell-cycle arrest, which was associated with strong induction of p21 and p27 and reduction of...
متن کاملLappaol F, a novel anticancer agent isolated from plant arctium Lappa L.
In an effort to search for new cancer-fighting therapeutics, we identified a novel anticancer constituent, Lappaol F, from plant Arctium Lappa L. Lappaol F suppressed cancer cell growth in a time- and dose-dependent manner in human cancer cell lines of various tissue types. We found that Lappaol F induced G(1) and G(2) cell-cycle arrest, which was associated with strong induction of p21 and p27...
متن کامل1 Lappaol F , a novel anticancer agent isolated from plant Arctium Lappa
Correspondence: Ying Huang, M.D., Ph.D. Department of Pharmacology, State University of New York, Upstate Medical University 750 E. Adams Street Syracuse, New York 13210, USA. Email: [email protected] CoCorrespondence: Yingjie Hu, Ph.D. Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China. E...
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The title compound {systematic name: (3R-trans)-4-[(3,4-dimethoxy-phen-yl)meth-yl]-3-[(4-hydr-oxy-3-methoxy-phen-yl)meth-yl]-4,5-dihydrofuran-2(3H)-one}, C(21)H(24)O(6), has a dibenz-yl-butyrolactone skeleton. The two aromatic rings are inclined at a dihedral angle of 68.75 (7)° with respect to each other. The lactone ring adopts an envelope conformation. A series of O-H⋯O and C-H⋯O hydrogen bo...
متن کاملA Novel Fructan Possessing DB Value from Roots of Arctium lappa L
A fructan named ALF was isolated from the roots of Arctium lappa L.. The structure of ALF was identified by analyses of methylation, GC-MS, and both 1 H and 13 C NMR spectroscopy. The results obtained indicated that ALF, comprised of D-fructose and D-glucose in the molar ratio of 14:1, was an inulin-type fructan, which was confirmed by the composition of 14 fructose residues linked by (2 1) gly...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2013
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-13-0552